if you use Windows Media Centerin Vista Home Premium or Vista UltimateThese keyboard shortcuts should send the mouse on vacation :)
Keyboard Shortcuts / Windows Media Center
Video and DVD
Ctrl+E = Go to Videos
Ctrl+Shift+M = Go to the DVD menu
Ctrl+Shift+P = Play video / DVD
Ctrl+P = Pause video / DVD
Ctrl+F = Go to the Next Chapter
Ctrl+B = Go to the previous Chapter
Ctrl+Shift+F = Fast-forward
Ctrl+Shift+S = Stop Video / DVD
Ctrl+Shift+B = Rewind
Ctrl+Shift+A = Change the DVD audio
Ctrl+U = Change DVD subtitles
Arrow Keys = Change the DVD angle
Television
Ctrl+T = Go to Live TV
Ctrl+O = Go to Recorded TV
Ctrl+G = Go to the Guide
Ctrl+R = Record the TV show
Ctrl+P = Pause the TV show
Ctrl+Shift+P = Resume a TV show
Ctrl+Shift+S = Stop recording or playing a TV show
Ctrl+Shift+F = Fast-forward
Ctrl+Shift+B = Rewind
Page Up = Go to the next channel
Page Down = Go to the previous channel
Ctrl+B = Skip back
Ctrl+F = Skip Forward
My C.
Ctrl+D = Display the content menu
Ctrl+Shift+C = Toggle closed captioning on / off
F8 = Mute Volume
F9 / F10 = Volume Up / Volume Down
Music (inc. Radio)
Ctrl+A = Go to radio
Ctrl+P = Pause music
Ctrl+M = Go to music
Ctrl+Shift+S = Stop Radio
Ctrl+Shift+P = Pause music
Ctrl+F = Go to the next song
Ctrl+B = Skip back
Ctrl+Shift+F = Fast-forward
Ctrl+R = Rip a CD
Pictures
Ctrl+Shift+P = Start the slideshow
Ctrl+Shift+S = Stop the slideshow
Ctrl+P = Pause the slideshow
Ctrl+I = Go to Pictures
